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Drinking water scams

 Can The Structure Of Water Be "Altered"
So It Is More (or less) Beneficial To Health?


Get the facts, or the facts will get you. And when you get them, get them right, or they will get you wrong.
(Dr. Thomas Fuller, Gnomologia, 1732)

  Drinking Water News

Altered Water Claims:
greater energy and vitality
increased hydration
enhanced oxygen delivery
better overall health
decreased stress levels
a more positive attitude
boosted metabolism
detoxification of the body
fewer negative emotions
normalize, maintain body pH
enhanced antioxidant activity
pain reduction
better more relaxed sleep
memory enhancement
greater strength
heightened endurance
a stronger immune system
protection from early aging
increased mobility
improve cellular electrical properties
softer smoother skin
increased absorption of nutrients
114o bond angle kills pathogens
water crystal structure changes in response to words
erase the negative imprinting in waters

I prepared the discussion below in response to questions visitors ask about the truth of claims made by manufacturers and distributors of altered or enhanced water products---or devices that allegedly enhance water. 

Promotions for these enhanced water products claim that the physical properties and/or energy characteristics of water molecules can be altered by some process to produce a wide range of general health benefits. Claims are also made that the structure/energy of water produced by distillation and reverse osmosis is actually harmful to health and that  'acidic' water is harmful or 'alkaline/ionized' water is beneficial to health.
 
The Bottom Line:
Can "enhanced" water products influence health?

Short answer: No - - - and Yes.
No: I have found absolutely NO reliable, published, reproducible, scientific evidence after years of searching the medical literature:
a) that any of the so-called "enhanced-water" treatment processes can restructure, energize or otherwise alter water to cause any health effects that are different from regular, untreated water in well-designed blinded studies.
b) that distillation or reverse osmosis creates water harmful to health.
c) that supports any theories to explain the alleged physical, energy, and chemical characteristics of 'altered' water products or the processes alleged to produce them.
d) that describes or demonstrates how any of the 'altered' water products might work in the body to produce the alleged benefits.
e) that alkaline or ionized water helps the body regulate pH.   More here
f) that homeopathic remedies are any more effective than placebos.

Altered Water Processes:
magnetized water
clustered water
energized water
structured water
Nikken Pi Mag water
photonic water activation
vibrationally charged water
hydrogenated water
vortex water
homeopathic treatments pro/con/skit/skeptic/more
ionized water
alkaline water
interactive water with intention
Beotron energy
oxygenated water
M-Activation Technology
imploding vortex
noble gas infusions
nano energizing frequency
Micowater
hexa structured water
Penta Water
Willard catalyzed water
John Ellis energized distilled water
Masaru Emoto: water crystals

Audio Slideshow
Quacks and Cures

 

and Yes: People may indeed experience perceived benefits after they drink enhanced/altered products like Nikken Pi Mag, Willard catalyzed, alkaline, oxygenated, John Ellis, Penta, or countless other 'flavors' of altered water.  The well documented placebo effect is powerful enough that people's expectations and beliefs about how a product will work can actually cause the expected experience. The placebo's evil twin the nocebo effect is probably responsible for any negative effects experienced from drinking water produced by distillation or reverse osmosis.  This article discusses the placebo effect and proposes a BEET score to rate the effectiveness of products that are able to trigger the placebo effect (placebo references). Penn and Teller's Placebo Effect episode further illustrates how suggestion and an uncritical willingness to believe can explain not only people's perceptions about bottled water but their acceptance of claims from downright fraudulent companies. The reality is that the alleged health effects for altered water products can not be distinguished from untreated water in well designed, blinded studies.

Where does that leave the consumer??
Often at the mercy of the altered/enhanced water merchant. Just one illustration of the dilemma:  Every shred of available scientific evidence supports the conclusion that the oxygen dissolved in bottles of "oxygenated water" would only benefit fish and other aquatic creatures. Yet perfectly intelligent people, who are not scientifically informed, report that they feel more energetic after paying for and drinking a $1.95 bottle of oxygenated water.


Companies market oxygenated water and similar products, consumers purchase and use them, some people report a benefit and continue to purchase the product, their testimonials are used to lure more customers, and the cycle continues. A very interesting and informative Reality TV Series could be developed to scientifically test the claims of a wide range of consumer products on volunteers and "publish" the results on National TV.  Unfortunately, that will never happen because the TV stations depend on advertising revenues from products with marketing claims that would be very susceptible to exposure as misleading at best and often downright fraudulent.


Your mind is perfectly capable of creating the same health benefits you would experience when drinking any of the enhanced or altered water products just by thinking about what you want to experience. It seems though, that for most people a 'prop' of some kind is necessary to jump-start the placebo effect and create the necessary expectation and beliefs that lead to a perceived health benefit. The altered/enhanced water products can provide effective but very expensive 'props'.  Their marketing materials skillfully use techniques proven to bolster belief and expectation; like a compelling story, credible-sounding (or at least impressive) descriptions of function and benefits, endorsement by individuals with impressive sounding credentials,  testimonials from satisfied customers, etc.
If there is magic on this planet, it is contained in water.
Loran Eisley, The Immense Journey, 1957
My suggestion:  If you are convinced that any of the altered water products are effective, you can save your money by focusing your thoughts on a glass of regular water. Water is a truly extraordinary and magical substance - all life depends on it.  So, take an ordinary glass of water and tap into that "magic"—meditate for awhile on the benefits you would like for it to create: drink the water: then experience exactly the same benefits as the altered water product would have produced.  If you need a 'prop' to trigger your mind's ability to create the health benefits attributed to altered/enhanced water products, check out the Water Mandala site.  Free Water Mandalas are offered with the claim that exposure of water (or other beverage) to a special mandala image will produce water with exactly the same physical and energy characteristics and will produce exactly the same health benefits as a wide range of altered or enhanced water products. An experimental design is also provided with details on how to compare the effects of the mandala-treated water with an enhanced/altered water product to minimize bias.

Other pages on this site that related to this topic include : Evaluating Altered Water Claims and How to Identify Water Scams. You might want to read pages 1 - 11 of the book, On Being a Scientist
(free to read online) for an important description of the characteristics that define good, ethical science.  Those who develop and market enhanced/altered water products almost never demonstrate these characteristics. This book provides an interesting introduction to the history of "snake oil" products.

In the expanded discussion of this topic below, the original questions are preserved along with the answers, because they provide a window into how the average consumer perceives these enhanced/altered water products.


Question 1   Answer 1

Randy,

I enjoyed your website about water.

I am looking for the best home water system and have run across a couple of interesting things.
First, I've heard that reverse osmosis renders water "dead" and can leach calcium from the consumer's bones. There is a system that uses technology used in Japan for 30 years that uses a magnetic field and Far Red light spectrum. I've tried a small cup of this water and it was amazing. The product is from Nikken (I think).

I've been trying to research water systems for about 3 or 4 months now and wondered if you've heard about this and have any thoughts about negative aspects. It seems that if water molecules are broken down into microclusters -- through magnets or electricity, the body is better able to utilize the water. I've tried the Royal Body Care microcluster liquid, and that seemed to help a bit with hydration. I've tried the Penta Water also, but the water is run through reverse osmosis - twice.

I'd appreciate any insight.

Margaret

Answer 1

Hi Margaret

I am glad you enjoyed my website.

Your questions actually fall into three categories:
1) the alleged positive alteration or enhancement of water structure &/or energy (apart from standard purification methods) that results in beneficial health effects.
2) the alleged negative alteration of water by certain treatment methods (usually distillation, reverse osmosis or municipal water treatment - sometimes even filtration), and the alleged negative health effects due to the altering of the water's structure or 'energy'.
3) the 'alleged leaching' of minerals out of the body by highly purified water (usually by Reverse Osmosis, Deionization or Distillation (RDD)). A corollary to that argument is that drinking RDD water is bad because the 'good minerals' critical to health (usually Calcium and Magnesium) are removed.  I cover this in another discussion about the health effects of drinking distilled water.


I guess the easiest way to approach the topic of alleged health benefits of altered water is to ask - What criteria would you, personally, accept as validation of the claims for a particular product?
Criteria a) Your own experience with the product.
Criteria b) The word of someone you know who experienced the product.
Criteria c) A celebrity endorsement or the word of a sales person.
Criteria d) A discussion on a website or in a book that lists the experiences of many people who used that product - Would it make a difference if the person making the claims has some higher degree (PhD, MD, DC, etc.) after his/her name?
Criteria e) A peer reviewed paper* in a medical or scientific journal that has looked at the blinded or double blinded** effects of the product on a large number of people and compared the measured effects to those from a control group of people who used a similar, but presumably inactive, mimic of the product being tested (a placebo). A cross-over component can also be added where the treatment is switched during the study (again the subjects and perhaps the experimenters unaware of the switch).
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* A peer reviewed paper means that a group of other experts in the field have examined the paper and agreed that proper methodology has been used and that valid conclusions have been reported. 

** A Blinded study means that the people in the experiment (the subjects) do NOT know whether they have been using the test product or the placebo. This is a critical element of a successful experiment, when possible, because it minimizes the very real 'placebo effect' (the observation that if a person thinks they are taking or doing something that "is supposed to be good for them" that beneficial effect is actually measured - even though they have taken an inactive material or done something that should not have an effect).  In a blinded study the experimenters do know which treatment the subjects were given.

A Double Blinded study means that neither the scientists administering the experiment nor the the subjects know whether they have been using the test product or the placebo. A double blind study minimizes the possibility that the study results could be biased by the knowledge of the experimenters or the analysis team regarding which treatment the subjects were given. Scientists typically do an experiment because they want to demonstrate that their theory (about a treatment for a specific disease, for example) is correct.  They are frequently very passionate about their theory and have invested a lot of time and money in developing the theory and designing the study.  They want it to work.... and they are human!  Consequently if those in charge of the experiment know which treatment is given to which subjects, there is the possibility that their desires for a specific outcome could influence the way data was collected, analyzed, and ultimately reported.

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This site provides a detailed procedure you can use to compare the effectiveness of products while minimizing bias.

A summary of the process to test claims for 'altered or enhanced' water using (Criteria e) would involve giving one group of subjects 'altered' water over a period of time and giving the control group the same amount of purified but not 'altered' water (without either the subjects or the experimenters knowing who is getting what). All product claims (more energy, better hydration, etc.) would be carefully measured and recorded for each group.

After several weeks, the water would be switched (without the subjects or experimenters knowing when) and measurements would continue. After the experiment was completed, the results would be tabulated and a preliminary analysis made of the measured outcomes.  Finally, the results would be unblinded and fully analyzed (blinding during the preliminary analysis phase minimizes any unconscious bias on the part of the statistician).  If there were real, beneficial health effects of the 'altered' water, the data would ONLY show real, positive differences in the results recorded when the subjects drank the 'altered' water.

To the best of my knowledge, there has never been a peer reviewed paper published in ANY medical or scientific journal that conclusively validates ANY of the physical or health claims made by the proponents of ANY of the various types of 'altered' water.
(Although an occasional supportive paper have been published, the conclusions have not been supported by subsequent studies - see below).

Altered/enhanced water companies usually support their claims with variations of criteria (a), (b), (c), or (d). These are examples of Anecdotal Evidence or Testimonials. You are basically taking someone's word that a product is effective (or relying on your own experience). 

Anecdotal evidence is not necessarily false or bad (in fact that is probably how most valid scientific theories got started), but with anecdotal evidence there is no way to determine whether the experienced effect was caused by the product, by chance, or because of an expectation of what the product should do - the placebo effect described below.

When health claims are made for expensive products with nothing but anecdotal evidence to support the claims, I am extremely skeptical. There is absolutely no enforced regulation of ANY of the claims made by these 'altered' water companies beyond those imposed on "normal" bottled water. The companies are usually very careful to state that "They do not make any claims that the product treats or cures a specific disease condition",  If they made such claims, they would be regulated by the FDA and would be required to provide scientific proof of the claims.

The companies typically follow that disclaimer, however, by stating "look what it has done for all these people" - and then let the anecdotal health claims "speak for themselves"

There are papers published in alternative health journals that seem to support health claims of some 'altered' water products. These journals are biased toward non-traditional treatment methods. That is not a bad thing, necessarily, but one important characteristic of good science is that the results of a study can be reproduced by anyone at any time whether they are skeptical of the outcome or biased toward it—that is why blinding is so important. Blinding minimizes bias in either direction.

The mainstream scientific and medical communities pretty much ignore experimental evidence found in papers in alternative health journals. That is not the case if the claims are published in a mainstream scientific or medical journal.  The scientific community will typically respond very quickly with a careful dissection of the study methods, results, analyses, and conclusions and then attempt to duplicate the study.

Mainstream scientific journals (which are skeptical toward 'altered' water claims) publish very few papers that seem to validate altered water product claims. 
No published altered water claims have been validated by later studies, to my knowledge.

One of the more notorious examples a mainstream journal that published a paper supporting 'altered' water claims is a 1988 paper in Nature that appeared to support the homeopathic claim that water can retain a memory of substances that were once dissolved in it.
E. Dayenas et. al. "Human basophil degranulization triggered by very dilute antiserum against IgE". Nature 333: 816–818.
The response from the scientific community was immediate, and many efforts to duplicate the study have failed.
The episode is described here.

Two arguments are typically used to explain why research from developers and promoters of altered water products is not found in mainstream scientific and medical journals:
1) Mainstream scientists do not understand our work and are biased against our findings.  The scientific community is closed, unwilling to consider new ideas, and our work will never be published regardless of how good it is.
2) Clinical trials are very expensive.  Many alternative products with great potential are developed by small companies that do not have the resources to conduct a study that will demonstrate the effectiveness of an alternative product to the satisfaction of the scientific community.

Neither excuse is convincing:
1) Science thrives on new ideas and theories. A discovery that the structure of water could be altered in some way to provide positive health effects and no negative side effects would be a huge discovery - front page, Nobel-worthy news.  The only catch is that any researcher in any country (not just in Japan) must be able to duplicate the methods and obtain the same results - and that has never been done.
2) The alternative health community apparently has never heard of venture capital.  A small, carefully designed blinded trial using a few dozen people that could demonstrate a significant positive effect of an altered/enhanced water product (and provide an understandable explanation of how it worked) would have investors lining up to fund a large study. The James Randi foundation has offered several enhanced water companies, including Penta Water, one million dollars if they could demonstrate that their product worked as advertised.  The companies were free to create their own experimental design and establish ANY outcome results and testing methods they chose - they only had to demonstrate that their product produced a significantly different outcome from the control group in a truly blinded study---there have been no takers on the challenge...

The financial rewards to a company that developed a proven, safe, inexpensive enhanced water product that met all criteria for scientific acceptance and provided a significant health benefit (that was different than the benefit of drinking untreated water) would be enormous.

The truth is, companies that manufacture and market 'altered' water products are not interested in performing experiments that will withstand skeptical scrutiny—most probably because they can't, but why bother even trying when people purchase their product anyway and report benefits. 

Scientists believe the claims of altered/enhanced water products to be non-issues - not worth bothering with, and are usually not willing to invest the time and money required to test the claims (the exception, as noted above, is when a paper supporting alternative water claims is published in a mainstream journal). Companies marketing the 'altered' water frequently state that scientific evidence is available to back their claims.  Be skeptical and try to actually locate and read the paper that supports the claim. If there is no link provided, ask the company for a copy of the paper, and (if you ever receive it) take it to a local science teacher to get another opinion.

There is an additional complication in trying to assess the effectiveness of certain products that claim to produce health benefits, the Placebo Effect.  The placebo effect is the observation that a person's expectation of how a product will work can sometimes cause the expected result even if the actual treatment was never administered.  For example, a sugar pill given as a pain reliever to someone with arthritis might cause a reduction of pain in some individuals.

It ironic that the scientific and medical communities understand and study the placebo effect but usually treat it as a nuisance that complicates "real" scientific experiments to develop "real drugs" that are proven more effective than the placebo - but often come with serious side effects.

The alternative health community, on the other hand, embraces (and exploits) the fact that the mind, with a little guidance to stimulate belief and expectation, is often able to produce real relief for many health conditions. Unfortunately, belief and expectation, no matter how positive, do not always heal, and a delay in seeking medical therapy with proven, effective medical treatments can lead to serious health problems.

There are several interesting debates in the scientific community regarding the ethics of doctor prescribed placebos
(also) and of the use of placebos in clinical trials (also) when effective non-placebo alternatives are available.

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You mentioned that you have had positive experiences with several of these 'altered' waters. Is it possible that your positive experiences could have been 'colored' by your expectations of what the water would/should do?  If you have access to some of these water types, you can do some double blinded experimenting on your own (neither you nor the person giving you the water samples would know which water you were drinking - and thus 'what to expect' from the water).

If you get together a small group of interested people, you might at least be able to test the idea (or hypothesis) that a person can tell by 'how they feel' if they are drinking 'altered' water or 'normal' water - the taste of the water would have to be very similar though.  This page provided a good outline of how to test and compare the effects of different products without introducing bias.


In answer to the claims that reverse osmosis (or distillation) renders water "dead" - I would generally use the same arguments as above. I have not heard of any 'vital force' being attributed to water (by scientists, anyway). Pure water will have a molecular structure of H2O and will be utilized equally well by the body regardless of treatment methods use whether traditional purification technologies are used (filtration, distillation, RO, etc.) or pseudo-scientific treatments as described in the references below. I discuss the topic of water treated with distillation and reverse osmosis on this page. Back to top

I hope this helps. If you have any further questions, let me know..

Best wishes.

Randy
randy@cyber-nook.com

  Response and Question 2:   Answer 2

Randy,

Wow, thank you for taking your time to answer my questions so thoroughly. You have given me more to think about. I'm looking for water that can hydrate, as I feel dehydrated. In Kentucky, I was able to get Highbridge Water and actually visited the source and the bottling facility located in a cave. It was run through reverse osmosis and ultraviolet light and seemed to hydrate pretty well.

The Penta Water hydrates a bit better, but is currently cost prohibitive to drink daily. I had no expectations when I drank water from the Nikken System and was skeptical. I was given 3 samples of different waters, and the Nikken water seemed like what my body was craving. I will follow your advise and see if I can obtain some scientific research on it.

For such an essential thing that we need to sustain life, the best drinking water is so elusive. I've learned over the years that just because something is put on a shelf in a store or on the market that it's not necessarily safe.

Thank you for your continued pursuit of the answers and for sharing your knowledge so freely.

Margaret

Answer 2:

Hi Margaret

I take the time to answer people who have questions in part because I am troubled by the rampant miss-information campaigns I see, not only on the internet, but in stores and in all the media.  A good proportion of the marketing campaigns seem to be designed exclusively to separate people from their money.

If you constantly feel dehydrated despite drinking plenty of water, there may be some physical problem causing the feeling rather than the type of water you are drinking. I am not a physician, so I won't even hazard a guess, but I thought I'd bring that up as a possibility to consider. 

Again, I encourage you to try some blinded tests over several day's of drinking various types of water to see if you can really tell the difference in the way the water hydrates your body in the absence of ANY clues as to which type of water you are drinking. It may be difficult to set up a truly blinded test though because, depending on the type or treatment and the materials left in (or removed from) the water samples - calcium, air, other trace minerals, etc. - the taste alone can provide clues to the type of water you are drinking. 

Even the faintest hint of a suggestion about what to expect can subtly influence the mind to interpret subsequent events a particular way.

For example, in your experience with Nikken Pi Mag water, did the sales representative walk in, immediately offer you three identical-looking glasses of water to drink (with absolutely no comments or explanations about what the samples were or what you might experience), and then ask you to record your impressions about each glass of water - again with no prompting about what you were drinking or what kinds of impressions to be thinking about?

That would be the ONLY way to reduce the possibility (probability) that the sales presentation influenced the outcome of the "test" - but then sales people are usually VERY interested in influencing the outcome of a demonstration!  I suspect the stage was carefully set by the sales person so you knew exactly what each glass contained and what you were supposed to experience.

The response (unconscious usually) of the mind to the 'power of suggestion' can not be over-emphasized - that's why some sales people are so effective, and why experimental studies are so difficult to set up - the experimenters, the subjects, and even the analysis team can be subtly and unconsciously influenced by the minds' expectations. An important part of the scientific review process I mentioned in my previous letter is to try to discover if expectations about the outcome of a study had any influence on how the scientists set up the study and recorded, analyzed, or interpreted the data. As one of the articles below mentions, "even the course of an illness" can be affected by the mind's ability to modify the body's response to an event (again, the placebo effect).

In the case of the "test" where you sampled Nikken Pi Mag water, any of the situations outlined below would be more than enough to predispose your mind to accept a particular sample as "better than" the others.

In the discussion below, situations 1 and/or 2 ' would set the stage' for the mind to be thinking about the great things that will happen when the Nikken water is sampled.
1) If the Nikken representative was pleasant, confident, and seemed to be extremely knowledgeable about his/her product and the way the body absorbs and metabolizes water.
2) If there was ANY DISCUSSION before you actually sampled the water about the treatment process, the benefits of the treated water and/or what was "supposed to happen" when the Nikken water was sampled.

Then, with a positive expectation, any knowledge about the identity of a sample (situations 3 and/or 4), no matter how slight, can allow a difference in the samples to be "detected".
3) If you saw the water samples prepared.
4) If there were ANY comments or hints made during the sampling, like "now, don't you feel great after that sample". It probably wouldn't be that blatant, but even subtle body language or an "expectant look" can give a hint as to the expected response to a sample. That's why double blinded experiments, where neither the experimenter nor the subject knows which treatment is given, are so important.


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Anyway, I wanted to reiterate my current thoughts and concerns on the subject of 'altered' water. To the best of my knowledge (and the water chemists I have contacted), as far as the body is concerned, water is water! You will want to drink pure, safe water, but I have not yet encountered ANY information (that I would accept as scientifically valid) that would convince me that there is any way to modify water so that it is either absorbed into the bloodstream from the intestines or into the cells themselves more efficiently than untreated water (or that it can move nutrients or waste products through the body any better). ANY WATER should hydrate your body and provide transport for nutrients, gases, and waste products perfectly well!   


Two facts that make it unlikely for the clustered water products you mention to have any effect on the body:

1) Even if there were some way to create special clusters (or other alterations) of water molecules, it is most unlikely that these carefully balanced "structures" would survive intact during the several hour journey through the acid contents of the stomach into the intestines where the water molecules are absorbed. I included a couple of references below that explain the stomach environment and the absorption process of water into the intestine.  I go into some detail about this idea in my discussion on distilled water.

2) Water absorption in the intestine is driven by osmosis - a passive process that depends (as far as is known) only on the concentrations of dissolved materials (or solutes) on either side of a membrane (the cells in the intestine and in the rest of the body). Basically, water molecules move from areas of low solute concentration into areas of high solute concentration. Cells in the intestine can increase the concentration of solutes within their membrane (by 'pumping' sodium in, for example), and the water follows by osmosis.  According to current theories of water transport into cells, special proteins form small channels in the membrane that are just large enough for single water molecules to fit through.

Promotional materials that claim their water product has a modified water cluster size do not even attempt to describe how those special clusters can improve the way water molecules enter cells or how the behave in the body to influence health.

The special clusters would have to disassemble to move out of the intestines, reassemble within the bloodstream for transport throughout the body, and disassemble again to move into other cells. The accepted model of water transport provides no mechanism to explain how water clusters or other forms of 'altered' water could possibly benefit to the body - even if the clusters could be created, stabilized, and controlled.

It is not possible for developers, producers, and marketers of altered/enhanced water products to integrate their fanciful theories and claims with conventional scientific theories, so they employ testimonials to support their claims and depend on the fact that the placebo effect will produce enough positive experiences to keep their products selling.


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If you are interested in exploring the "science" of these 'altered' waters, try to find someone at one of the companies who is willing and able to provide a detailed explanation of:
1) How the water's special structure is stabilized so it survives an hour or so in the stomach - a highly acidic environment containing digestive enzymes and other molecules and ions.
2) A mechanism that describes specifically how the altered structure of the water interacts with cell membranes to facilitate transport across the intestinal cell walls and into the bloodstream.  Does the 'structure' cross the intestinal wall intact or reassemble in the bloodstream?
3) Once in the blood stream, exactly how is the special structure of the water maintained?
4) Exactly how does the special structure of the water cause the claimed benefits - what are specific effects of the altered water molecules on the metabolic processes?
5) Results from double-blind trials of their product, preferably peer reviewed, to ensure impartiality and published in a reputable journal, but I would settle for a good description of the experimental method employed.

If you are able to get an explanation that addresses any of the questions above (or similar questions that you devise), I would be EXTREMELY INTERESTED in receiving a copy of the communication and the person's name and e-mail address.

I do not claim to know everything about this subject, but I do know enough to be extremely skeptical about certain claims without very good evidence to back up those claims. There is an important saying in the scientific community "Extraordinary Claims Demand Extraordinary Proof".  Claims made by manufacturers and marketers of 'altered' water can be said to be "Extraordinary" because they fall outside the scope of mainstream scientific theories and conventional understanding of how the world "works".

Consequently, in order for the mainstream scientific and medical communities to accept any of the altered water claims as valid, those who produce and promote the products must:
a) provide very convincing evidence that the products work in blinded trials - and demonstrate that the results can be reproduced.
b) provide convincing theories that explain the physics and chemistry behind the processes used to produce the products. There has not even been any evidence provided by producers of altered water products that they would be able to correctly and consistently select their their product from a sample of ordinary water in a blinded test.
c) describe exactly how the products work in the body to produce the alleged benefits.

So far, none of the the developers and/or promoters of any product you mentioned nor any of the other products on the market for which similar claims are made has been able to address any one of the three criteria above to the satisfaction of the mainstream scientific and medical communities.

Homeopathic remedies are an excellent example of a well established altered water product that does not meet any of the criteria necessary for acceptance by the mainstream science and medical communities.  Specifically:
a) There are no examples of repeatable, well designed and executed blinded trials which demonstrate that homeopathic remedies work any better than placebos.
b) There has never been a testable theory presented that would explain how a substance that is diluted beyond the point where any of the original molecules are present could have any influence on the structure of water (or on a homeopathic pill from which the water has been removed). "Water memory" has been suggested, but no explanation of how that might work has been proposed.
c) There have been no theories offered to explain how a homeopathic preparation might act in the body to cause reported health benefits.

Hope this additional information helps

Best wishes for your quest into pure, healthful water

Randy

Reference below for:
   Homeopathic products
   Placebo Effect
   Digestion and water absorption
   Aquaporins {water pores in cell membranes - RJ}

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Several  relevant references:
Aqua Scams
The purpose of this site is to examine the scientific validity of the explanations given by the proponents of "alternative" water treatment devices or, in the case of "clustered water", of a fictional alternative form of water that is purported to be a restorer of youth and vigor. My motivation for doing this is entirely non-vested and very simple: after thirty-four years of teaching general, physical, and environmental Chemistry, it disturbs me to see my favorite science presented incorrectly (and often mangled into pseudoscience) in the promotion of processes or devices offered to the public.  Also take a look at his Clustered Water discussion and general comments on water.  

Kangen Water: Change Your Water, Change Your Life: A scientific look at one of the latest multilevel marketing fads: healing water machines, devices costing thousands of dollars claiming to ionize or alkalize your tap water, and claiming a dazzling range of health and medical benefits. Sold under such names as Kangen, Jupiter Science, KYK, and literally hundreds of others, these machines do either nothing or almost nothing (beyond basic water filtration), and none of what they may actually do has any plausible beneficial purpose.

A good PowerPoint discussion on different water-related scams from the Alabama State Water Program.

A somewhat less skeptical treatment of "altered water" topics - also a good source of water information:
Water structure and behavior:  "A number of explanations of the complex behavior of water have been published, many quite recently. In this site, I have brought together a self-consistent selection of these ideas, which I hope will encourage both the understanding of water and further work."

This book pretty much sums up the points made above about conducting scientific research and publishing results in an honest, open manner that invites scrutiny of the methods, analysis, results, and conclusions.  Those who develop and market altered water products typically make no attempt to follow even the basic principles outlined in the first 11 pages of this book.

"The scientific research enterprise is built on a foundation of trust. Scientists trust that the results reported by others are valid. Society trusts that the results of research reflect an honest attempt by scientists to describe the world accurately and without bias. But this trust will endure only if the scientific community devotes itself to exemplifying and transmitting the values associated with ethical scientific conduct..."
Read More

A good summary of the book can be found in the Introduction and Treatment of Data chapters.

The references below (and the claims quoted) are listed for information only, and definitely DO NOT represent my endorsement of (or belief in the value of) the products! - RJ

I'll mention one specific type of 'altered water' here because I actually listened to an early promotional tape in the late 90s that consisted of an interview with the 'creator' of the water. In my opinion, the interview was a very clever mix of truth, nonsense, and truth used in the wrong way (that is, true statements used improperly to support a particular point).

2009 Update - Penta Water has toned down its marketing rhetoric over the past few years.  Current marketing claims on the home page no longer seem to reference the original alleged characteristic that gave the product its name, small clusters of 5 water molecules that the company originally claimed were more easily absorbed by the body.  as of 11/2011 Claims of a 30% smaller cluster size can, however still be found on the bottled water website as well as claims that, "It has also been observed that Penta has a higher boiling point and higher viscosity than normal water."
2009 claims on the company website: Penta Water is ultra purified, energized water that not only fully hydrates, but may also help increase antioxidant activity in your body. During the last decade, The Penta Water Company has received numerous reports from consumers regarding the positive effects of drinking Penta. These various comments include references to feelings of more energy, a greater sense of well-being, and even improved appearance of skin.

"Penta Water is first cleaned using a state of the art purification system to remove all impurities. No other bottled water is as pure! The water then goes through the patented Penta process which spins the water at high speed and pressure for 11 hours, and as a result increases antioxidant activity."
A current (2009) page on the
bottled water website describes a different process "Penta is the only bottled water that uses physics, not chemicals, to restructure its water. The water is cycled through the Penta Process until a specific set point of thermal energy is released for approximately 7-8 hours.
2009 product claims on the bottled water website include:


"Proof that Penta is restructured water: Penta has been shown through highly technical scientific testing (Raman spectroscopy) to have 30 percent smaller molecular water clusters. It has also been observed that Penta has a higher boiling point and higher viscosity than normal water. Penta's unique structure is also patented and has been verified in a published, peer-reviewed study conducted by scientists at Moscow's General Physics Institute.
Research has shown that Penta water's unique properties provide the following benefits:
* In-vitro studies show an increase in cell survivability by 266%.
* In-vitro studies show that Penta water dissolves calcium oxalate monohydrate (the main substance in 85% of kidney stones) three times faster than normal water.
* In-vitro studies on human cells reveal that lab distilled water DNA chromosomal mutation rates were 271% greater than Penta water.
In addition, countless Penta drinkers have told us that, by effectively hydrating, they look and feel more youthful, energetic and all around better.

The James Randi Educational Foundation includes an interesting discussion on Penta Water and describes the Foundation's attempts to persuade the company to participate in their million dollar challenge. http://www.randi.org/jr/08-24-01.html, http://www.randi.org/jr/08-31-01.html, http://www.randi.org/jr/110201.html (about 3/4 of the way down), http://www.randi.org/jr/083002.html (about 1/2 of the way down) and http://www.randi.org/jr/121903lins.html ( just over 1/2 of the way down).

Here's another type of clustered water - a concentrate, no less.  Just add concentrated water to a glass of water...
"Science" according to Zunami™ bottled water
:  In the human body, there are two basic types of water (biowater): Bound water and Clustered Water. Clustered Water(tm) is able to move freely through the cell walls(a) and is necessary to transport nutrients, remove waste, and maintain proper communication between the cells.  Bound water, on the other hand, is water that becomes physically bound to other molecular structures and is unable to move freely through the cell walls(b).  When we are young, our bodies contain a high level of this remarkable water and very little bound water.* However, as we age, bound water becomes more predominant and free water levels decrease, hindering the effectiveness of literally thousands of metabolic functions and causing significant structural changes in our body’s tissues.
Zunami™ is highly purified water that has been raised to a high level of electromagnetic power through a proprietary process, the result is Hexa Structured Water™. No preservatives or additives are used in this process. It is this restructuring that makes these products so effective in accelerated hydration through enhanced mobility. The process begins with extremely pure distilled water and, while it is exposed to special lasers and extremely strong magnetic fields to create stable water "clusters". Most water is in organizations or clumps of 60 or more water molecules (H2O). The process is designed to structure the water molecules into clusters that are very mobile, therefore entering the cell system very rapidly(a) and replenishing inter-cellular water.
{A real bargain at only $40 for 4 gallons - RJ}
Never mind the company has the biology completely backwards.  In truth:

a) Water clusters can not move freely through the cell wall - water moves through cell membranes as single molecules.
b)
The text above makes "bound water" seem like a problem.  However, water that is bound to proteins and other macro molecules in the cell is necessary for them to function properly.


I can not find anything on the sites below that describes how the magnetic or far-infrared technologies of Nikken's water system actually works. From what I can tell, it is mostly a carbon block filter - and a very expensive one at that (over $900 with shipping), with expensive replacement filters. I could not discover the pore size, but from the contaminants removed, I would expect it would be 1 micron or smaller.   My ideas about the additional 'altering' of the water by the other elements of the filter would fall into the discussion above..

The references below are listed for information only, and definitely DO NOT represent my endorsement of (or belief in the value of) this product! - RJ

PiMag Water System: PiMag water also offers more. Decades ago, scientists discovered that the water in a remote area of Japan produced amazing results on the surrounding plants. They named it pi water. Nikken has succeeded in replicating the environment that created pi water in nature, and these discoveries are incorporated in PiMag products. You will taste and feel the difference!

2009 update: Nikken, like Penta Water, has toned down the rhetoric on its corporate site over the past few years and now provides very few details on the processes involved in producing PiMag water.

One way to determine the actual performance of a product is to look at the independent certification.  NSF certification of the Nikken water system.
Type Nikken into the 'MANUFACTURER' search box and clicked on 'Search by Manufacturer'.

The results in 2009 for the Pi-Mag 13151 and Pi-Mag 13155 cartridges were:
Standard 42 - Aesthetic Effects
   Chlorine Reduction, Class I
   Nominal Particulate Reduction, Class I
   Taste and Odor Reduction
Standard 53 - Health Effects
   Cyst Reduction
   Lead Reduction
   MTBE Reduction
   Turbidity Reductionion
   VOC Reduction

Compare that with the NSF certification for the Solid Block Activated Carbon filter I recommend:  It's a high-end and fairly expensive filtration system at $400 - yet less than 1/2 the cost of the Nikken filter.

The certified list of contaminants removed by the standard CB6AD filter cartridge is:
For Standard 042 - aesthetic
   Chlorine Reduction, Class I
   Particulate Reduction, Class I
   Chloramine Reduction
   Taste and Odor Reduction
For Standard 053 - contaminants of health concern
   Asbestos Reduction
   Chlordane Reduction
   Cyst Reduction
   Lead Reduction
   Mercury Reduction
   MTBE Reduction
   PCB Reduction
   Toxaphene Reduction
   Turbidity Reduction
   VOC Reduction (volatile organic chemical) Reduction - you will see a long list of specific VOCs


My Day with the Homeopaths - Part I - by Steven Novella
Yesterday I took part in a panel discussion titled, A Debate: Homeopathy - Quackery Or A Key To The Future of Medicine? hosted by the University of Connecticut Medical Center. You might think that the title is a bit of a false dichotomy, but in this case it is accurate, for the two sides of this debate occupied far ends of the belief spectrum with a wide gulf between us.

After my presentation on the extreme scientific implausibility of homeopathy, materials scientist Rustum Roy presented his completely unconvincing case for its plausibility. His strategy was to argue that the only significant scientific objection to homeopathy (other than the blind bias, prejudice, “homeophobia” - his term, and materialistic assumptions of scientists) is that homeopathic water does not contain any molecules of active ingredient. However, he argues, the key to material function is not composition but structure, so we should be looking at the structure of water and not what is in it...
My Day with the Homeopaths - Part II - by Steven Novella
Donald Marcus from Baylor did an excellent job of presenting a review of the clinical evidence for homeopathy, accurately conveying that the evidence is largely negative. Iris Bell, a protege of Andrew Weil from the University of Arizona, had the job of distorting and cherry picking the clinical evidence to make is seem as if it supports homeopathy. Her strategy was typical, standard fare for CAM proponents.

First, she argued that we should accept clinical observations as reliable evidence. These are open-label or uncontrolled case reports, essentially the clinical experience of homeopaths. This is all a fancy way of saying anecdotal evidence, which over a century of scientific medicine has taught us is completely unreliable. I think anecdotes are worse than unreliable - they tend to lead us to conclusions we wish to be true rather than those that are true, and they can cause a false sense of confidence in the unwary.

One of the more notorious examples a mainstream journal that published a paper supporting 'altered' water claims is a 1988 paper in Nature that appeared to support the homeopathic claim that water can retain a memory of substances that were once dissolved in it.
E. Dayenas et. al. "Human basophil degranulization triggered by very dilute antiserum against IgE". Nature. 1988 Jun 30;333(6176):816-8. The latter can be demonstrated at dilutions of anti-IgE that range from 1 x 10(2) to 1 x 10(120); over that range, there are successive peaks of degranulation from 40 to 60% of the basophils, despite the calculated absence of any anti-IgE molecules at the highest dilutions. Since dilutions need to be accompanied by vigorous shaking for the effects to be observed, transmission of the biological information could be related to the molecular organization of water.
The response from the scientific community was immediate, and many subsequent efforts to duplicate the study have failed. The episode is described here, here, and here.

BBC Horizon show tries to win James Randi's 1 million dollar challenge in 2002 by proving homeopathy works. History & challenge; YouTube #1, #2, #3 #4, #5; Transcript of the event; James Randi's summary.

Dr. Ben Goldacre weighs in on homeopathy.


The Placebo Effect  Doctors in one study successfully eliminated warts by painting them with a brightly colored, inert dye and promising patients the warts would be gone when the color wore off. In a study of asthmatics, researchers found that they could produce dilation of the airways by simply telling people they were inhaling a bronchiodilator, even when they weren't. Patients suffering pain after wisdom-tooth extraction got just as much relief from a fake application of ultrasound as from a real one, so long as both patient and therapist thought the machine was on. Fifty-two percent of the colitis patients treated with placebo in 11 different trials reported feeling better -- and 50 percent of the inflamed intestines actually looked better when assessed with a sigmoidoscope ("The Placebo Prescription" by Margaret Talbot, New York Times Magazine, January 9, 2000).
Forty years ago, a young Seattle cardiologist named Leonard Cobb conducted a unique trial of a procedure then commonly used for angina, in which doctors made small incisions in the chest and tied knots in two arteries to try to increase blood flow to the heart. It was a popular technique -- 90 percent of patients reported that it helped -- but when Cobb compared it with placebo surgery in which he made incisions but did not tie off the arteries, the sham operations proved just as successful. The procedure, known as internal mammary ligation, was soon abandoned ("The Placebo Prescription" by Margaret Talbot, New York Times Magazine, January 9, 2000).
{Excellent description, discussion, and examples - RJ}

Placebo effects - Background:  The benefits of therapeutic interventions in clinical practice are often enhanced by placebo effects. Placebo effects can be defined as the positive physiological or psychological changes associated with the use of inert medications, sham procedures, or therapeutic symbols within a healthcare encounter. Placebos can also be active substances or real procedures that produce unexpected beneficial effects. For example, antibiotics may be considered placebos when prescribed for viral respiratory illnesses that are not expected to respond to antibiotic action. Placebo effects may also be viewed as a subset of a larger group of mind-brain-body effects such as the psycho-physiological effects of religious beliefs and devotional practices, meditation, faith-based healing, hypnosis, and the effects of cultural and social economic systems on the prevalence and severity of specific diseases.
These effects have been scientifically documented by an increasing body of research. Mind-brain-body effects, including placebo effects, are not fully appreciated in contemporary medicine. {continues with an interesting description of the effect}

How People Are Fooled by Ideomotor Action - Ideomotor Action: The "influence of suggestion in modifying and directing muscular movement, independently of volition" - an interesting phenomenon related to the placebo effect.  This article describes experiments that show how a person's beliefs and expectations affect how their muscles behave.
More here - Without Volition: The Presence and Purpose of Ideomotor Movement - Ideomotor action is referred to as "mischief-making" because its unrecognized presence is actually the reason movement occurs in activities such as dowsing, the play with the Ouija board and "facilitated communication." In fact, any activity in which movement is thought to be caused by forces that transcend our senses or are described as metaphysical in nature should be suspected to begin with movement that we don't consciously plan. The word volition is especially important to this concept. Defined as "the power of choosing; the act of making a choice or decision; willful," volition is subtly different than simple reflexive activity thought not to include the higher centers of the brain. And, like a simple reflex, ideomotor movement occurs instinctively, though it is often far more complex and always without volition. This is the primary reason those doing it do not commonly take responsibility for its manifestation or consequence. We suppose ourselves to be consciously in control of our movement for the most part, and it is difficult to convince people otherwise under ordinary circumstances.

The Mysterious Placebo - One of the most significant but widely misunderstood phenomena is the placebo effect. Research shows that the placebo effect can be greater and is far more ubiquitous than commonly thought. More articles about the Placebo from the Committee for Skeptical Inquiry (CSI).  The CSI mission is to promote scientific inquiry, critical investigation, and the use of reason in examining controversial and extraordinary claims.

From Placebo to Homeopathy: The Fear of the Irrational The placebo effect is a perfect illustration of scientific exorcism of a disturbing fact (W.A. Brown, Scientific American, Jan. 1998, pages 68-73). Although its existence has been established beyond doubt, all efforts are directed not toward studying its mechanisms, but to subtracting its interference. (subscription required)

Scientific Framework of the Placebo Effect, by Gershom Zajicek, The Cancer Journal - Vol10:5
The placebo effect is "any dummy medical treatment; originally, a medicinal preparation having no specific pharmacological activity against the patient's illness. . .". This definition summarizes the attitude of modern medicine to a placebo: a useless and undesired side-effect of treatment. Which is unfortunate, since a placebo promotes healing. It may relieve pain, e.g., headache, and even modify the course of an illness. However, medicine regards it as a sham treatment, tainted with deception. Placebo is Latin for "I shall please", and was used in the past to please the patient. Even as late as 1950, catalogs for physicians carried long arrays of pills labeled "Placebo". All this has now vanished and placebo as such is not used.

More on the Placebo Effect - {interesting, but a bit difficult to follow the lines of thought - RJ}


Absorption of Water and Electrolytes: The small intestine must absorb massive quantities of water. A normal person or animal of similar size takes in roughly 1 to 2 liters of dietary fluid every day. On top of that, another 6 to 7 liters of fluid is received by the small intestine daily as secretions from salivary glands, stomach, pancreas, liver and the small intestine itself.

Water and nutrient absorption: An important function of both small intestine and colon is the absorption of water and electrolytes. Approximately 2000 ml of food and drink is ingested daily, and the volume of gastrointestinal secretions (salivary, gastric, biliary, pancreatic and intestinal) is about 8,000 ml daily; therefore, approximately 10 liters of fluid enters the intestine each day. Of the 8 liters secreted, about 1-1.5 liters enter as saliva, 2-3 liters are secreted by the stomach, about 2 liters enter as bile and pancreatic secretion (about 1 liter each), and about 2 liters are secreted by the small intestine.  (Please note that these figures are approximate, not absolute. Volumes may vary, depending on experimental method and conditions.) Of the 10 liters which enters the gut each day, only about 1 liter passes into the colon, about 90% having been absorbed across the small intestinal epithelium. Only about 150 ml is lost in the feces daily, with the remainder being absorbed by the colon. It should be obvious that any derangement in intestinal fluid absorption would profoundly influence the balance of fluid and electrolytes in the body, and that the normal functioning of the intestines plays a significant role in regulating water and electrolyte balance. The net absorption or net secretion of water in the intestine is the result of bidirectional movements of water from mucosa to serosa (m-->s flux or absorption) and from serosa to mucosa (s-->m flux or secretion). In the human intestine, these unidirectional fluxes exceed net movement 2-3 fold.  The rate and direction of net fluid movement depend on tonicity of the meal, and move toward the achievement of isotonicity {equal concentration of water on both sides of a membrane - RJ}
The intestinal mucosal surface consists of a bimolecular lipid membrane, which (presumably) contains small pores or channels. Water and water-soluble substances can hypothetically enter the cell through these pores only, while lipid-soluble substrates can directly cross the lipid cell membrane. Specialized protein pores, referred to as aquaporins (AQP) have been identified in many tissues, including colon epithelium; water channel isoforms in small intestinal epithelium remain to be discovered. Intestinal absorption of water is a passive process and requires movement of solutes. Water accompanies solute and moves across the intestinal mucosa in response to osmotic gradients. The rate of water uptake in any region of the intestine is a function of solute absorption in this region. All areas of the intestines (including small bowel and colon) absorb water, the relative amounts absorbed depending on the presence of solutes {things dissolved in water, sodium, calcium, sugar, etc. - RJ}, and the types of solutes present. In the jejunum, the active transport of sugars and amino acids causes passive movement of salt and water, which accounts for most of the water uptake in this area. In the ileum, most water movement is accounted for by active sodium transport. As described in Johnson (Gastrointestinal Physiology), coupled water and sodium transport involves a specialized mechanism that pumps sodium into the lateral spaces, resulting in relatively high osmotic pressure in that region. Water then enters the lateral space from the cell (transcellular flux) and--perhaps--the lumen (paracellular flux), reducing the osmotic pressure but increasing the hydrostatic pressure. Fluid is then forced out of the lateral space into the interstitial space. The net effect is that isotonic fluid is transported from the lumen into the extracellular fluid. This hypothesis of fluid absorption is illustrated in Figure 12-5, on page 137 of the Johnson resource.

The Digestive System - Interesting tour of the digestive system (part 2).


Aquaporins - the perfect water filters of the cell 
Aquaporins are water channel proteins; they are located in the otherwise water impermeable cell membrane of many plants and animals. There they prevent bursting of the cells, e.g., due to changes of the exterior salt concentration (osmotic regulation). In humans, aquaporins regulate the water flux in the kidney, red blood cells, the eye lens, and the brain, to name just a few..... *** The structure showed that the protein forms a channel in the membrane that is 2 nanometers (billionth meter) long and 0.3 nanometers wide, just large enough for water molecules to fit through, such that permeation of larger molecules is prevented.***
{This site has some neat diagrams!  One reason that clustered water is unlikely to have an effect on the cell's intake of water - H2O molecules appear to cross the cell membrane singly, not as clusters - RJ}

Aquaporins are proteins embedded in the cell membrane that regulate the flow of water. They are "the plumbing system for cells." Aquaporins are integral membrane proteins from a larger family of major intrinsic proteins (MIP) that form pores in the membrane of biological cells.

Aquaporins: Water Channels - Water crosses cell membranes by two routes: by diffusion through the lipid bilayer and through water channels called aquaporins. Functional characterization of the first aquaporin was reported in 1992, but water channels were suspected to exist well before that time, because the osmotic permiability of some types of epithelial cells was much too large to be accounted for by simple diffusion through the plasma membrane. A single human aquaporin-1 channel facilitates water transport at a rate of roughly 3 billion water molecules per second. Such transport appears to be bidirectional, in accordance with the prevailing osmotic gradient.

The Art of Water Transport in Aquaporins - Aquaporins are membrane water channels that play critical roles in controlling the water contents of cells. These channels are widely distributed in all kingdoms of life, including bacteria, plants, and mammals. More than ten different aquaporins have been found in human body, and several diseases, such as congenital cataracts and nephrogenic diabetes insipidus, are connected to the impaired function of these channels.

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Updated November 2011